Monsters vs. Aliens

Susan Murphy (Reese Witherspoon) is hit by a radioactive meteor on the day of her wedding to weatherman Derek Dietl (Paul Rudd), absorbing a substance called quantonium and growing into a giantess. Alerted to the meteor crash, the military arrive and capture Susan. She is labeled a monster, renamed "Ginormica", and sent to a top-secret facility containing other monsters: B.O.B. (Seth Rogen), a brainless, indestructible gelatinous blob; Dr. Cockroach, Ph.D. (Hugh Laurie), a mad scientist with the head and abilities of a cockroach; the Missing Link (Will Arnett), an amphibious fish-ape hybrid; and Insectosaurus, a colossal grub that is even larger than Susan. The monsters are forbidden to have any contact with the outside world; while the other monsters have been living contentedly with this lifestyle for the past 50 years, Susan feels incredibly isolated and immediately misses her family, friends, and fiancé.

An alien named Gallaxhar (Rainn Wilson) detects the quantonium radiation emanating from Earth and deploys a gigantic robotic probe to find it and extract it from its source, Susan. After a botched attempt by the President of the United States (Stephen Colbert) to make first contact with the robot, it begins destroying everything in sight. General W.R. Monger (Kiefer Sutherland), head of the monster-containment facility, convinces the President to use the monsters to fight the robot. The monsters accept the mission with the promise of freedom if they succeed. Arriving in San Francisco, Susan is chased by the robot across the city to the Golden Gate Bridge, where the monsters are able to defeat the robot.

Now free, Susan reunites with her family and introduces them to the monsters, who are dejected after innocently causing a panicked ruckus. She meets up with Derek but he breaks up with her to prevent her from overshadowing his career. Heartbroken, Susan meets up with the other monsters when she is abducted by Gallaxhar, who kills Insectosaurus when he tries to save her. After being chased around the ship by Susan, Gallaxhar extracts the quantonium from her body, returning her to her normal size. He then proceeds to clone himself into an army so he can invade Earth.

B.O.B., the Missing Link and Dr. Cockroach infiltrate Gallaxhar's ship and rescue Susan. The monsters flee into the ship's power core where they hack into the control system and activate the ship's self-destruct sequence. Susan escapes but the other three are trapped. Susan confronts Gallaxhar, who tries to escape with the quantonium, and attempts to force him into releasing her friends. When Gallaxhar says he cannot reverse the sequence, Susan takes the quantonium back and absorbs it, restoring her to her gargantuan size and allowing her to save her friends. The monsters leap out of the exploding ship and are rescued by General Monger on the back of the newly-revived Insectosaurus, who had sealed his own body in a cocoon and transformed into a flying butterfly-like form.

The monster team receives a hero's welcome upon their return. Derek attempts to get back with Susan for the sake of interviewing her that could benefit his career; insulted, Susan publicly humiliates him instead, declaring her place is with her monster friends. At that moment, the team is alerted to a monster attack near Paris and set off to combat the new menace.